Classification:
Burkitt lymphoma can be divided into three main clinical variants:
1) Endemic variant
2) Sporadic type and
3) Immunodeficiency -associated variants.
- The Endemic variant
- The Sporadic type of Burkitt lymphoma.
- Immunodeficiency-associated Burkitt lymphoma.
For the purpose of deciding how much treatment is necessary Burkitt lymphoma may be divided into 3 groups:
- Group A
– Any localized tumor that has been completely removed by surgery
- Group B
– Any tumor that has not been removed by surgery and does not involve the nervous system or more than 25% of the bone marrow
- Group C
– Any lymphoma with at least 25% bone marrow involvement or with any brain or spinal involvement
The level of an enzyme in the blood called LDH can be elevated in Burkitt lymphoma. Children with an LDH more than twice the normal level have higher risk disease.